Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y12 receptor. … Visa mer In the US, ticagrelor is indicated to reduce the risk of stroke in people with acute ischemic stroke or high-risk transient ischemic attack. In the EU, ticagrelor, co-administered with acetylsalicylic acid … Visa mer Contraindications to ticagrelor are active bleeding, increased risk of bradycardia, concomitant therapy of ticagrelor and strong cytochrome P-450 3A (CYP3A4) inhibitors and … Visa mer Inhibitors of the liver enzyme CYP3A4, such as ketoconazole and possibly grapefruit juice, increase blood plasma levels of ticagrelor and consequently can lead to bleeding and other adverse effects. Ticagrelor is a weak CYP3A4 inhibitor and is known to increase … Visa mer Comparison with related drugs With clopidogrel The PLATO trial concluded superiority of ticagrelor compared to clopidogrel in reducing the rate of death from vascular causes, MI, and stroke in people presenting with … Visa mer The common adverse effects are increased risk of bleeding (which may be severe) and shortness of breath (dyspnoea). … Visa mer Mechanism of action Like the thienopyridines prasugrel, clopidogrel and ticlopidine, ticagrelor blocks Visa mer Ticagrelor is a nucleoside analogue: the cyclopentane ring is similar to the sugar ribose, and the nitrogen rich aromatic ring system resembles the nucleobase purine, giving the molecule … Visa mer WebbThe reversible binding allows ticagrelor to redistribute to new platelets as they are formed. 1 It is not known how pharmacology or chemical class correlates to clinical efficacy or …

Efficacy versus safety: the dilemma of using novel platelet …

Webb15 nov. 2024 · Ticagrelor is a prescription medication used to treat Acute Coronary Syndrome or History of Myocardial Infarction (MI), Coronary Artery Disease, Acute … WebbTicagrelor is in a class of medications called antiplatelet medications. It works by preventing platelets (a type of blood cell) from collecting and forming clots that may … expert monitor gaming

Ticagrelor reduces myocardial infarction. Medical search.

WebbCurrent Therapeutic Targets for Alzheimer's Disease; Research Highlights. ... HSP40 Proteins Use Class-Specific Regulation to Drive HSP70 Functional Diversity; IL-33-PU.1 … Webb18 nov. 2024 · Therapeutic Class: Platelet Aggregation Inhibitor Pharmacologic Class: ADP-Induced Aggregation Inhibitor Uses for ticagrelor Ticagrelor is used alone or … WebbTicagrelor is a P2Y 12 receptor antagonist that prevents ADP-mediated P2Y 12 dependent platelet activation and aggregation. Indications and dose Prevention of atherothrombotic … bty1566