WebProduct Description The PathScan ® Phospho-Survivin (Thr34) Sandwich ELISA Kit is a solid phase sandwich enzyme-linked immunosorbent assay (ELISA) that detects endogenous … WebAug 22, 2024 · To gain insight into potential mechanisms that led to the reduction of pDARPP32-Thr34, we explored major regulators of DARPP32 phosphorylation in MSN cultures. Protein phosphatase 3 (PP3, formerly PP2B), is known to dephosphorylate DARPP32-Thr34 in a Ca 2+-dependent manner
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WebDopamine and cAMP-regulated phosphoprotein of Mr 32,000 (DARPP-32) plays an obligatory role in most of the actions of dopamine. In resting neostriatal slices, cyclin-dependent kinase 5 (Cdk5) phosphorylates DARPP-32 at Thr-75, thereby reducing the efficacy of dopaminergic signaling. We report here that dopamine, in slices, and acute … toy jeep wrangler unlimited
Promotion of ubiquitination-dependent survivin destruction …
WebMay 14, 2024 · Mutation of Thr34 to Ala promoted survivin ubiquitination and reduced protein half-life, which may contribute to xanthohumol-mediated anti-tumor activity in vitro and in vivo. However, based on our current data, we could not exclude the possibility that xanthohumol reduced survivin phosphorylation on other serine or threonine sites. WebSynthetic phospho-peptide corresponding to amino acid residues surrounding Thr34 conjugated to KLH. Validations. None available. Applications. Western Blotting (WB) Reactivity. Rattus norvegicus (Rat) Additional product information. Synonyms protein phosphatase 1, regulatory (inhibitor) subunit 1B, Darpp-32, Darpp32. WebSep 14, 2010 · Here, we demonstrated that the PC12-NCS-1 cells have a reduced level of pDARPP-32(Thr34) compared to untransfected PC12 (Fig. 4a, d). However, the phosphorylation of DARPP-32 at the Thr34 can also be regulated by PP-2B. Increases in intracellular Ca 2+ levels activate PP-2B, which dephosphorylates pDARPP-32(Thr34) … toy jobs near me