Cytoplasmic sox10

Author: wnqm

August undefined, 2024

SOX10 is used as an immunohistochemistry marker, being positive in: • Neuroectodermal neoplasms of neural crest origin, especially: Melanoma, although desmoplastic melanomas may be only focally positive. Nevus • SOX10 immunohistochemistry in a dermal nevus, showing positively stainin… WebMay 5, 2009 · Others have shown that Sox10 is a nucleocytoplasmic shuttling protein. We extend this observation and demonstrate that, in the cytoplasm, Sox10 is peripherally associated with the mitochondrial outer membrane. Both Sox10 and ARMCX3 are expressed in mouse brain and spinal cord as well as several cell lines. Overexpression …

SOX10 Gene - GeneCards SOX10 Protein SOX10 Antibody

WebAug 27, 2024 · Animal studies have indicated that SOX10 is one of the key transcription factors regulating the proliferation, migration and differentiation of multipotent neural … WebDec 31, 2024 · In ARM, cytoplasmic SOX10 was co‐expressed with neuronal antigens in ~57% of submucosal and myenteric neurons, vs. ~3% in control. Furthermore, intrinsic gut neurons in ARM specimens co‐expressed PLP1 (18%) and CDH19 (18%); however, neuronal co‐expression of PLP1 and CDH19 was rarely (<2%) observed in controls. shannon imhoff

An Immunohistochemical Comparison Study of SOX10, Pan …

WebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nu- cleocytoplasmic shuttling ... WebJun 20, 2014 · Cytoplasmic staining for the pan-melanoma cocktail and nuclear staining for SOX10 and MITF were scored by 2 pathologists (J.C. and Y.G.). Positive staining in >1% … WebFeb 6, 2024 · the cytoplasm of both Fbxo9- and Sox10-expressing cells compared. to predominant nuclear localization of Neurog2 in the vector control (Fig. 4 A and B). In contrast, the number of HuC/D + shannon imlach

SOX10: a useful marker for identifying metastatic …

Immunohistochemical Staining for SOX10 and SDHB in …

WebSOX10 and S100 both stained 100% of DM and SCM, whereas Pan Melanoma stained 50% (Figure 3, Table 1). Normal lymph node was negative for SOX10 and Pan Melanoma but … WebOct 1, 2012 · Sox10 is a marker of neural crest origin and is expressed in melanoma and peripheral nerve sheath tumors. •. This article explores Sox10 expression in various … shannon imagesWebIn addition, a fourth pattern with cytoplasmic AE1/AE3 and nuclear SOX10 was observed in a subset of carcinomas, most notably triple-negative breast cancers. Conclusions: … shannon imaging center

"WebFeb 6, 2024 · The relocalization of ectopic Neurog2 from the nucleus to the cytoplasm suggests the possibility that overexpression of Sox10 promotes ubiquitination of Neurog2, which could occur in both compartments as evidenced by another short-lived bHLH transcription factor, MyoD ( 26 ). " - Cytoplasmic sox10

Cytoplasmic sox10

Transcription factor profiling identifies Sox9 as regulator of

WebSep 15, 2015 · Whereas SOX10 has a nuclear localisation in the embryonic neural crest, hEPI-NCSC showed predominantly cytoplasmic SOX10 immunoreactivity. WNT and SHH signalling are part of the network that regulates SOX10 expression ( Werner et al., 2007 ; McNeill et al., 2012 ), which explains the increased nuclear SOX10 localisation in hEPI … WebSOX10 and S100 both stained 100% of DM and SCM, whereas Pan Melanoma stained 50% (Figure 3, Table 1). Normal lymph node was negative for SOX10 and Pan Melanoma but was strongly positive for S100 (Figure 4). The melanoma triple cocktail (Fast Red only) and the sequential double stain of SOX10 (DAB) and Pan Melanoma

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WebAug 20, 2015 · Results: SOX-10 showed exclusive nuclear positivity in 100% of the uveal melanoma cases (38/38). HMB-45 showed cytoplasmic positivity in 97.3 (37/38). … WebNov 29, 2024 · SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and inter …

WebThis granular cell tumor shows strong nuclear and cytoplasmic expression in virtually all of the tumor cells. The tumor cells surround a small peripheral nerve , which also expresses … WebJul 6, 2024 · In postnatal mice, melanocytes maintain and are maintained by expression of high levels of Sox10, while Sox10 activity in melanocyte stem cells is decreased 38. It is commonly accepted that ...

WebIn accord with its function as transcription factor, Sox10 contains two nuclear localization signals and is most frequently detected in the nucleus. In this study, we report that … WebApr 5, 2013 · Appropriate positive and negative controls were used for each antibody. Nuclear staining of >10% tumor cells was considered positive for SOX10 and p63; cytoplasmic staining for Smooth muscle actin...

WebDec 3, 2024 · SOX10, located at 22q13.1, has five transcripts (splice variants), 67 orthologs, and 16 paralogs. As a nucleocytoplasmic shuttle protein, SOX10 is of great significance to the development of the neural crest, the peripheral nervous system, and melanocytes ( Castillo and Sanchez-Cespedes, 2012 ).

WebJun 19, 2024 · In contrast to S100, which is expressed in both the nucleus and cytoplasm, SOX10 is confined to the nucleus, enabling double staining to be performed on paraffin … polyurethane stain home depotWebApr 4, 2024 · Orthologous to human SOX10 (SRY-box transcription factor 10). [provided by Alliance of Genome Resources, Apr 2024] Sox10 SRY (sex determining region Y)-box 10 [ (house mouse)] Gene ID: 20665, updated on 4-Apr-2024. Summary. ... and nervous system development. Located in cytoplasm and nucleus. Is extrinsic component of … shannon inciWebNov 4, 2024 · SOX10 positivity is also commonly expressed in both mixed tumors and myoepitheliomas (~80%), but is only present in a minor percentage of myoepithelial carcinomas (Fig. 3f) . Other markers of ... polyurethane stained by inkWebNordic Immunohistochemical Quality Control, SOX10 run 60 2024 Page 1 of 9 Assessment Run 60 2024 Transcription factor SOX-10 (SOX10) Purpose Evaluation of the technical performance, level of analytical sensitivity and specificity of IHC tests among ... a weak cytoplasmic staining reaction of ganglion/neuronic cells in the appendix was accepted ... shannon imxWebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nucleocytoplasmic shuttling activity. An interspecies heterokaryon analysis was performed as originally described by Pinol-Roma and Dreyfuss . polyurethanes technical conferenceWebSOX10. −: − ± ... The cytoplasm is usually amphophilic and granular due to their secretory content. MTCs routinely express neuroendocrine markers as well as signs of thyroid differentiation (TTF1), whereas monoclonal PAX8 expression is lacking, as is thyroglobulin (the latter a consequence of the non-follicular cell origin). ... shannon imaging center radiology mammographyWebMar 21, 2024 · SOX10 (SRY-Box Transcription Factor 10) is a Protein Coding gene. Diseases associated with SOX10 include Peripheral Demyelinating Neuropathy, Central … polyurethane spray paint walmart